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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1349671
Species: Homo sapiens
CRRD Object: Gene
Symbol: TAF1
Name: TATA-box binding protein associated factor 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceISORGD:15620506480464CTDTAF1 protein results in decreased susceptibility to Doxorubicin

PMID:15124910
increases expressionISORGD:15582346480464CTDDoxorubicin results in increased expression of TAF1 mRNA

PMID:15124910
increases expressionISORGD:15620506480464CTDDoxorubicin results in increased expression of TAF1 protein

PMID:15124910
multiple interactionsISORGD:15620506480464CTD[roscovitine results in decreased activity of CDK2 protein] inhibits the reaction [TAF1 protein results in decreased susceptibility to Doxorubicin], Doxorubicin promotes the reaction [TAF1 protein results in increased expression of CCNE1 protein], TAF1 protein mutant form inhibits the reaction [Doxorubicin results in increased activity of CDK2 protein], TAF1 protein promotes the reaction [Doxorubicin results in increased activity of CDK2 protein]

PMID:15124910
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.