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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3427
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Psmb9
Name: proteasome 20S subunit beta 9
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:111806480464CTDDoxorubicin results in decreased expression of PSMB9 mRNA, Doxorubicin results in decreased expression of PSMB9 protein

PMID:25896364
increases expressionISORGD:111806480464CTDDoxorubicin results in increased expression of PSMB9 mRNA

PMID:27155237
multiple interactionsISORGD:111806480464CTDPSMB9 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein], PSMB9 protein inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein], PSMB9 protein inhibits the reaction [Doxorubicin results in increased expression of BAX protein], PSMB9 protein inhibits the reaction [Doxorubicin results in increased expression of MAP3K5 protein], PSMB9 protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]

PMID:25896364
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.