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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3461
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Pygm
Name: glycogen phosphorylase, muscle associated
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7373296480464CTDDoxorubicin results in decreased expression of PYGM mRNA

PMID:26537877, PMID:28940058, PMID:29803840, PMID:30031762
increases expressionISORGD:7373306480464CTDDoxorubicin results in increased expression of PYGM protein

PMID:21251210
multiple interactionsISORGD:7373306480464CTDsodium nitrate inhibits the reaction [Doxorubicin results in increased expression of PYGM protein]

PMID:21251210
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.