Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620575
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDoxorubicin results in increased expression of APAF1 protein

PMID:22015447, PMID:25169008
multiple interactionsEXP 6480464CTDPropofol inhibits the reaction [Doxorubicin results in increased expression of APAF1 protein]

PMID:22015447
increases expressionISORGD:7332936480464CTDDoxorubicin results in increased expression of APAF1 mRNA

PMID:15939500, PMID:16001973
multiple interactionsISORGD:7332936480464CTDpluronic block copolymer p85 promotes the reaction [Doxorubicin results in increased expression of APAF1 mRNA]

PMID:15939500
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.