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CRRD ID: 620575
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDoxorubicin results in increased expression of APAF1 protein

PMID:22015447, PMID:25169008
multiple interactionsEXP 6480464CTDPropofol inhibits the reaction [Doxorubicin results in increased expression of APAF1 protein]

increases expressionISORGD:7332936480464CTDDoxorubicin results in increased expression of APAF1 mRNA

PMID:15939500, PMID:16001973
multiple interactionsISORGD:7332936480464CTDpluronic block copolymer p85 promotes the reaction [Doxorubicin results in increased expression of APAF1 mRNA]

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.