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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 732487
Species: Homo sapiens
CRRD Object: Gene
Symbol: TGM2
Name: transglutaminase 2
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceEXP 6480464CTDTGM2 protein affects the susceptibility to Doxorubicin

PMID:17073438
increases expressionEXP 6480464CTDDoxorubicin results in increased expression of TGM2 mRNA

PMID:15870702, PMID:29803840
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.