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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61800
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Htr2a
Name: 5-hydroxytryptamine receptor 2A
Acc ID: CHEBI:28790
Term: serotonin
Definition: A primary amino compound that is the 5-hydroxy derivative of tryptamine.
Chemical ID: MESH:D012701
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDSerotonin binds to HTR2A protein

PMID:8627522
affects response to substanceEXP 6480464CTDHTR2A protein affects the susceptibility to Serotonin

PMID:16528294, PMID:8627522
multiple interactionsEXP 6480464CTD[Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in decreased abundance of Serotonin], [Ketanserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Serotonin, Phenoxybenzamine affects the reaction [Serotonin binds to HTR2A protein]

PMID:16528294, PMID:19879056, PMID:8627522
affects response to substanceISORGD:7341076480464CTDHTR2A protein affects the susceptibility to Serotonin

PMID:16314884
decreases response to substanceISORGD:7341076480464CTDHTR2A gene SNP results in decreased susceptibility to Serotonin

PMID:16314884
increases expressionISORGD:620926480464CTDSerotonin results in increased expression of HTR2A mRNA

PMID:21083617
multiple interactionsISORGD:620926480464CTDHTR2A protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]

PMID:11880652
multiple interactionsISORGD:7341076480464CTD[Serotonin binds to and results in increased activity of HTR2A protein] which results in increased expression of and results in increased secretion of IL6 protein, Serotonin binds to and results in increased activity of HTR2A protein

PMID:11076827, PMID:16314884
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.