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CRRD ID: 2482
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:28834
Term: deoxycholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.
Chemical ID: MESH:D003840
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDDeoxycholic Acid results in decreased activity of CYP7A1 protein

decreases expressionISORGD:104586480464CTDDeoxycholic Acid results in decreased expression of CYP7A1 mRNA

PMID:20671298, PMID:21914718, PMID:25582706
decreases expressionISORGD:692106480464CTDDeoxycholic Acid results in decreased expression of CYP7A1 mRNA

PMID:14684751, PMID:25055961
multiple interactionsISORGD:104586480464CTD[Deoxycholic Acid results in increased activity of NR1H4 protein] which results in increased expression of CYP7A1 mRNA, SLCO1A1 protein affects the susceptibility to [Deoxycholic Acid results in decreased expression of CYP7A1 mRNA]

PMID:21914718, PMID:22531947
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.