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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 628831
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Acc ID: CHEBI:28834
Term: deoxycholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.
Chemical ID: MESH:D003840
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDDeoxycholic Acid results in decreased expression of NR1H4 mRNA

PMID:27743861
multiple interactionsEXP 6480464CTD[Cholic Acids co-treated with Deoxycholic Acid] results in decreased expression of NR1H4 mRNA

PMID:28391356
increases activityISOCRRD:7341036480464CTDDeoxycholic Acid results in increased activity of NR1H4 protein

PMID:17567710, PMID:22561792, PMID:27871908
increases activityISOCRRD:7341046480464CTDDeoxycholic Acid results in increased activity of NR1H4 protein

PMID:22531947
increases expressionISOCRRD:7341036480464CTDDeoxycholic Acid results in increased expression of NR1H4 mRNA

Deoxycholic Acid results in increased expression of NR1H4 protein

PMID:14684751, PMID:25055961
multiple interactionsISOCRRD:7341036480464CTD[[Deoxycholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoter] which results in increased expression of FGF19 mRNA

[Deoxycholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoter

Deoxycholic Acid analog binds to and results in increased activity of NR1H4 protein

Deoxycholic Acid binds to and results in increased activity of NR1H4 protein

Deoxycholic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]

PMID:13130122, PMID:22561792, PMID:25257666
multiple interactionsISOCRRD:7341046480464CTD[Deoxycholic Acid results in increased activity of NR1H4 protein] which results in increased expression of CYP7A1 mRNA

PMID:22531947
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