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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2482
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:28865
Term: taurocholic acid
Definition: A bile acid taurine conjugate of cholic acid that usually occurs as the sodium salt of bile in mammals.
Chemical ID: MESH:D013656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTaurocholic Acid results in decreased expression of CYP7A1 mRNA

PMID:7832767
decreases expressionISORGD:104586480464CTDTaurocholic Acid results in decreased expression of CYP7A1 mRNA

PMID:16284190
multiple interactionsISORGD:104586480464CTDFGFR4 protein affects the reaction [Taurocholic Acid results in decreased expression of CYP7A1 mRNA], NR1H4 protein affects the reaction [Taurocholic Acid results in decreased expression of CYP7A1 mRNA]

PMID:16284190
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.