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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3845
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tf
Name: transferrin
Acc ID: CHEBI:28984
Term: aluminium atom
Definition: A boron group element atom that has formula Al.
Chemical ID: MESH:D000535
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingISORGD:114066480464CTDTRF protein binds to Aluminum

PMID:15149824
affects bindingISORGD:13425936480464CTDAluminum binds to TF protein, TF protein binds to Aluminum

PMID:11193083, PMID:12627980, PMID:19859668, PMID:2039817, PMID:22873711, PMID:2308257, PMID:8782865
increases uptakeISORGD:13425936480464CTDTF protein results in increased uptake of Aluminum

PMID:1375080
multiple interactionsISORGD:13425936480464CTD[Aluminum binds to TF protein] which results in decreased uptake of Iron, [Aluminum binds to TF protein] which results in decreased uptake of Manganese, [Aluminum binds to TF protein] which results in increased uptake of Aluminum, [TF protein binds to Aluminum] affects the activity of [TF protein binds to Iron], [TF protein binds to Aluminum] which results in increased uptake of Aluminum, [TF protein binds to Aluminum] which results in increased uptake of Iron, [TF protein binds to and results in increased uptake of Aluminum] which results in decreased secretion of PTH protein, TF protein binds to [Aluminum co-treated with Iron], TF protein binds to and results in increased uptake of Aluminum

PMID:10978387, PMID:11193083, PMID:2039817, PMID:2308257, PMID:8782865
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.