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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3845
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tf
Name: transferrin
Acc ID: CHEBI:29035
Term: manganese(2+)
Definition: A divalent metal cation in which the metal is manganese.
Chemical ID: MESH:D008345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases uptakeEXP 6480464CTDManganese results in increased uptake of TF protein

PMID:17469137
multiple interactionsEXP 6480464CTD[Iron deficiency co-treated with Manganese] results in increased expression of TF protein

PMID:17060373
affects bindingISORGD:13425936480464CTDManganese binds to TF protein, TF protein binds to Manganese

PMID:18546093, PMID:8782865
multiple interactionsISORGD:13425936480464CTD[Aluminum binds to TF protein] which results in decreased uptake of Manganese, [Manganese binds to TF protein] which results in decreased uptake of Manganese

PMID:8782865
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.