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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 68321
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Sec61a1
Name: Sec61 translocon alpha 1 subunit
Acc ID: CHEBI:29320
Term: calcium(0)
Definition: An elemental calcium that has formula Ca.
Chemical ID: MESH:D002118
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases transportISORGD:13518136480464CTDSEC61A1 protein results in increased transport of Calcium

PMID:26085089
multiple interactionsISORGD:13518136480464CTD[HSPA5 protein binds to SEC61A1 protein] which results in decreased transport of Calcium, [SEC61A1 protein results in increased transport of Calcium] which results in increased susceptibility to Thapsigargin, DNAJB11 protein inhibits the reaction [SEC61A1 protein results in increased transport of Calcium], DNAJC3 protein inhibits the reaction [SEC61A1 protein results in increased transport of Calcium]

PMID:26085089
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.