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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1312909
Species: Homo sapiens
CRRD Object: Gene
Symbol: KBTBD7
Name: kelch repeat and BTB domain containing 7
Acc ID: CHEBI:2948
Term: azathioprine
Definition: A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Chemical ID: MESH:D001379
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KBTBD7decreases expressionEXP 6480464CTDAzathioprine results in decreased expression of KBTBD7 mRNA

PMID:22623647
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