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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 619755
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Rac1
Name: Rac family small GTPase 1
Acc ID: CHEBI:2948
Term: azathioprine
Definition: A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Chemical ID: MESH:D001379
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingISORGD:16054326480464CTDAzathioprine metabolite binds to RAC1 protein

PMID:12697733
affects response to substanceISORGD:16054326480464CTDRAC1 gene polymorphism affects the susceptibility to Azathioprine

PMID:21372752
decreases activityISORGD:16054326480464CTDAzathioprine results in decreased activity of RAC1 protein

PMID:12697733
multiple interactionsISORGD:16054326480464CTDAzathioprine inhibits the reaction [RAC1 protein binds to STAT3 protein]

PMID:12697733
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.