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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1303075
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Hsp90ab1
Name: heat shock protein 90 alpha family class B member 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDsodium arsenite results in increased expression of HSP90AB1 protein

PMID:16456883
multiple interactionsEXP 6480464CTDBenzo(a)pyrene promotes the reaction [sodium arsenite results in increased expression of HSP90AB1 protein], sodium arsenite promotes the reaction [Benzo(a)pyrene results in increased expression of HSP90AB1 protein]

PMID:16456883
decreases expressionISORGD:13468936480464CTDsodium arsenite results in decreased expression of HSP90AB1 protein

PMID:21925251
decreases expressionISORGD:15525916480464CTDsodium arsenite results in decreased expression of HSP90AB1 mRNA

PMID:18996350
increases expressionISORGD:13468936480464CTDsodium arsenite results in increased expression of HSP90AB1 mRNA

PMID:12119132
increases expressionISORGD:15525916480464CTDsodium arsenite results in increased expression of HSP90AB1 mRNA

PMID:16014739, PMID:16322246
multiple interactionsISORGD:15525916480464CTDATM protein affects the reaction [sodium arsenite results in decreased expression of HSP90AB1 mRNA], CHEK2 protein affects the reaction [sodium arsenite results in decreased expression of HSP90AB1 mRNA], sodium arsenite promotes the reaction [TRP53 protein binds to HSP90AB1 promoter]

PMID:18996350
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.