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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620897
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Dusp1
Name: dual specificity phosphatase 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:7329556480464CTDsodium arsenite results in decreased expression of DUSP1 mRNA

sodium arsenite results in decreased expression of DUSP1 protein

PMID:10764629, PMID:18812580
increases expressionISOCRRD:7329546480464CTDsodium arsenite results in increased expression of DUSP1 mRNA

PMID:12377979, PMID:16966095
increases expressionISOCRRD:7329556480464CTDsodium arsenite results in increased expression of DUSP1 mRNA

PMID:16014739
multiple interactionsISOCRRD:7329546480464CTDTP53 protein promotes the reaction [sodium arsenite results in increased expression of DUSP1 mRNA]

PMID:16966095
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.