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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 733705
Species: Homo sapiens
CRRD Object: Gene
Symbol: CTNNB1
Name: catenin beta 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationEXP 6480464CTDsodium arsenite affects the localization of CTNNB1 protein

PMID:22859221
decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of CTNNB1 protein

PMID:23219847, PMID:25879800
increases expressionEXP 6480464CTDsodium arsenite results in increased expression of CTNNB1 protein

PMID:16054901, PMID:22859221, PMID:24961358, PMID:29107899, PMID:31120745
multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite affects the localization of CTNNB1 protein], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [sodium arsenite results in decreased expression of CTNNB1 protein], Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of CTNNB1 protein], tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of CTNNB1 protein]

PMID:22859221, PMID:23219847, PMID:24961358
affects expressionISORGD:15504666480464CTDsodium arsenite affects the expression of CTNNB1 mRNA

PMID:16507464, PMID:28206643
decreases expressionISORGD:15504666480464CTDsodium arsenite results in decreased expression of CTNNB1 mRNA, sodium arsenite results in decreased expression of CTNNB1 protein

PMID:23143138, PMID:27158593
decreases expressionISORGD:704876480464CTDsodium arsenite results in decreased expression of CTNNB1 mRNA

PMID:23137061
increases expressionISORGD:15504666480464CTDsodium arsenite results in increased expression of CTNNB1 mRNA

PMID:25825268
multiple interactionsISORGD:15504666480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [sodium arsenite results in decreased expression of CTNNB1 protein], [Folic Acid co-treated with sodium arsenite] results in increased methylation of CTNNB1 mRNA

PMID:22959928, PMID:23143138
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.