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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730881
Species: Homo sapiens
CRRD Object: Gene
Symbol: HRAS
Name: HRas proto-oncogene, GTPase
Acc ID: CHEBI:29699
Term: tunicamycin
Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Chemical ID: MESH:D014415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:107306480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Tunicamycin co-treated with HRAS protein] results in increased expression of PCNA protein], [Tunicamycin co-treated with HRAS protein] results in decreased phosphorylation of MAPK1 protein, [Tunicamycin co-treated with HRAS protein] results in decreased phosphorylation of MAPK3 protein, [Tunicamycin co-treated with HRAS protein] results in increased expression of EIF2AK3 protein, [Tunicamycin co-treated with HRAS protein] results in increased expression of ERN1 protein, [Tunicamycin co-treated with HRAS protein] results in increased expression of HSPA5 protein, [Tunicamycin co-treated with HRAS protein] results in increased expression of PCNA protein, [Tunicamycin co-treated with HRAS protein] results in increased phosphorylation of AKT1 protein, [Tunicamycin co-treated with HRAS protein] results in increased phosphorylation of RB1 protein, HSPA5 protein affects the reaction [[Tunicamycin co-treated with HRAS protein] results in increased phosphorylation of AKT1 protein], HSPA5 protein affects the reaction [[Tunicamycin co-treated with HRAS protein] results in increased phosphorylation of RB1 protein]

PMID:24898257
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.