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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1321823
Species: Homo sapiens
CRRD Object: Gene
Symbol: DACT2
Name: dishevelled binding antagonist of beta catenin 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DACT2increases mutagenesisEXP 6480464CTDBenzo(a)pyrene results in increased mutagenesis of DACT2 gene

PMID:25435355
DACT2decreases expressionISORGD:13218246480464CTDBenzo(a)pyrene results in decreased expression of DACT2 mRNA

PMID:22228805
DACT2multiple interactionsISORGD:13218246480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of DACT2 mRNA]

PMID:22228805
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.