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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1605955
Species: Homo sapiens
CRRD Object: Gene
Symbol: PPCS
Name: phosphopantothenoylcysteine synthetase
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of PPCS promoter

PMID:30157460
increases expressionISORGD:15531396480464CTDBenzo(a)pyrene results in increased expression of PPCS mRNA

PMID:19770486
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