Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620575
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7332936480464CTDBenzo(a)pyrene results in decreased expression of APAF1 mRNA

PMID:20064835
increases expressionISORGD:7332936480464CTDBenzo(a)pyrene results in increased expression of APAF1 mRNA, Benzo(a)pyrene results in increased expression of APAF1 protein

PMID:21393351, PMID:30659931
increases expressionISORGD:7332946480464CTDBenzo(a)pyrene results in increased expression of APAF1 mRNA

PMID:19770486, PMID:21964900
multiple interactionsISORGD:7332946480464CTD[Benzo(a)pyrene co-treated with sodium bichromate] results in increased expression of APAF1 mRNA

PMID:22613061
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.