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CRRD ID: 620575
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7332936480464CTDBenzo(a)pyrene results in decreased expression of APAF1 mRNA

increases expressionISORGD:7332936480464CTDBenzo(a)pyrene results in increased expression of APAF1 mRNA, Benzo(a)pyrene results in increased expression of APAF1 protein

PMID:21393351, PMID:30659931
increases expressionISORGD:7332946480464CTDBenzo(a)pyrene results in increased expression of APAF1 mRNA

PMID:19770486, PMID:21964900
multiple interactionsISORGD:7332946480464CTD[Benzo(a)pyrene co-treated with sodium bichromate] results in increased expression of APAF1 mRNA

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.