GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620707
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tff1
Name: trefoil factor 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISOCRRD:7320176480464CTDBenzo(a)pyrene affects the expression of TFF1 mRNA

PMID:20127859
increases expressionISOCRRD:13446716480464CTDBenzo(a)pyrene results in increased expression of TFF1 mRNA

PMID:22316170
increases expressionISOCRRD:7320176480464CTDBenzo(a)pyrene results in increased expression of TFF1 mRNA

PMID:23735875
multiple interactionsISOCRRD:13446716480464CTDBenzo(a)pyrene promotes the reaction [ESR1 protein binds to TFF1 promoter]

PMID:16972788
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.