GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621113
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ttl
Name: tubulin tyrosine ligase
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects methylationISOCRRD:7321126480464CTDBenzo(a)pyrene affects the methylation of TTL intron

PMID:30157460
decreases expressionISOCRRD:7321136480464CTDBenzo(a)pyrene results in decreased expression of TTL mRNA

PMID:22228805
multiple interactionsISOCRRD:7321136480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TTL mRNA

PMID:27858113
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.