GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 708428
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Akr1c3
Name: aldo-keto reductase family 1, member C3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:13528886480464CTDBenzo(a)pyrene results in decreased expression of AKR1C3 mRNA

PMID:30439556
decreases expressionISOCRRD:7332906480464CTDBenzo(a)pyrene results in decreased expression of AKR1C18 mRNA

PMID:22228805
increases expressionISOCRRD:13528886480464CTDBenzo(a)pyrene results in increased expression of AKR1C3 mRNA

PMID:20106945, PMID:21632981, PMID:22316170, PMID:26238291, PMID:30439556
multiple interactionsISOCRRD:13528886480464CTD[Butyric Acid co-treated with Benzo(a)pyrene] results in increased expression of AKR1C3 mRNA

[Particulate Matter co-treated with Benzo(a)pyrene] results in increased expression of AKR1C3 mRNA

[Vehicle Emissions co-treated with Benzo(a)pyrene] results in increased expression of AKR1C3 mRNA

Benzo(a)pyrene promotes the reaction [Butyric Acid results in increased expression of AKR1C3 mRNA]

Butyric Acid inhibits the reaction [Benzo(a)pyrene results in increased expression of AKR1C3 mRNA]

Butyric Acid promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1C3 mRNA]

PMID:17612574, PMID:30439556
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.