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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 733444
Species: Mus musculus
CRRD Object: Gene
Symbol: Tpcn1
Name: two pore channel 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tpcn1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of TPCN1 mRNA

PMID:22228805
Tpcn1affects methylationISORGD:13440846480464CTDBenzo(a)pyrene affects the methylation of TPCN1 exon

PMID:30157460
Tpcn1increases expressionISORGD:13440846480464CTDBenzo(a)pyrene results in increased expression of TPCN1 mRNA

PMID:22316170
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.