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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:3011
Term: benazepril
Definition: A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.
Chemical ID: MESH:C044946
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDbenazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 mRNA], benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 protein]

PMID:16732983, PMID:20821936
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.