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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2482
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:30185
Term: zinc(0)
Definition: An elemental zinc that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDZinc results in decreased activity of CYP7A1 protein

PMID:1175606
increases expressionISORGD:692106480464CTDZinc deficiency results in increased expression of CYP7A1 mRNA

PMID:18356318
multiple interactionsISORGD:692106480464CTD[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CYP7A1 mRNA

PMID:16979875
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.