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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:30614
Term: benzo[a]pyrene diol epoxide I
Definition: An epoxide that has formula C20H14O3.
Chemical ID: MESH:D015123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTD7, 8-Dihydro-7, 8-dihydroxybenzo(a)pyrene 9, 10-oxide results in decreased expression of EGFR mRNA

PMID:19150397
multiple interactionsEXP 6480464CTD7, 8-Dihydro-7, 8-dihydroxybenzo(a)pyrene 9, 10-oxide results in increased phosphorylation of and results in increased activity of EGFR protein, EGFR mutant form inhibits the reaction [7, 8-Dihydro-7, 8-dihydroxybenzo(a)pyrene 9, 10-oxide results in increased phosphorylation of and results in increased activity of AKT1 protein], EGFR mutant form inhibits the reaction [7, 8-Dihydro-7, 8-dihydroxybenzo(a)pyrene 9, 10-oxide results in increased phosphorylation of and results in increased activity of MAPK1 protein], EGFR mutant form inhibits the reaction [7, 8-Dihydro-7, 8-dihydroxybenzo(a)pyrene 9, 10-oxide results in increased phosphorylation of and results in increased activity of MAPK3 protein], MUC1 mutant form inhibits the reaction [7, 8-Dihydro-7, 8-dihydroxybenzo(a)pyrene 9, 10-oxide results in increased phosphorylation of and results in increased activity of EGFR protein]

PMID:22457794
multiple interactionsISORGD:105116480464CTD7, 8-Dihydro-7, 8-dihydroxybenzo(a)pyrene 9, 10-oxide inhibits the reaction [EGF protein binds to EGFR protein]

PMID:6309801
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.