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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1625869
Species: Mus musculus
CRRD Object: Gene
Symbol: Mir491
Name: microRNA 491
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mir491decreases methylationISORGD:16037786480464CTDArsenic Trioxide results in decreased methylation of MIR491 gene

PMID:25196641, PMID:25304214
Mir491increases expressionISORGD:16037786480464CTDArsenic Trioxide results in increased expression of MIR491 mRNA

PMID:24680928, PMID:25196641, PMID:25304214
Mir491multiple interactionsISORGD:16037786480464CTD[Arsenic Trioxide results in decreased methylation of MIR491 gene] which results in increased expression of MIR491 mRNA, [Arsenic Trioxide results in increased expression of MIR491 mRNA] which results in decreased expression of SMAD3 mRNA, MIR491 affects the reaction [Arsenic Trioxide results in decreased expression of SMAD3 mRNA], MIR491 affects the reaction [Arsenic Trioxide results in decreased expression of SNAI1 mRNA], MIR491 mRNA affects the reaction [Arsenic Trioxide results in decreased expression of MMP2 mRNA], MIR491 mRNA affects the reaction [Arsenic Trioxide results in decreased expression of MMP9 mRNA], MIR491 mRNA affects the reaction [Arsenic Trioxide results in decreased expression of SNAI1 protein], MIR491 mRNA affects the reaction [Arsenic Trioxide results in decreased expression of SNAI2 protein], MIR491 mRNA affects the reaction [Arsenic Trioxide results in decreased expression of VIM protein], MIR491 mRNA affects the reaction [Arsenic Trioxide results in decreased phosphorylation of and affects the localization of RELA protein], MIR491 mRNA affects the reaction [Arsenic Trioxide results in increased expression of CDH1 protein], MIR491 mRNA promotes the reaction [Arsenic Trioxide results in decreased expression of IL6 mRNA], MIR491 mRNA promotes the reaction [Arsenic Trioxide results in decreased expression of SMAD3 mRNA], MIR491 mRNA promotes the reaction [Arsenic Trioxide results in decreased expression of VEGFA mRNA], S-Adenosylmethionine inhibits the reaction [Arsenic Trioxide results in increased expression of MIR491 mRNA]

PMID:24680928, PMID:25196641, PMID:25304214
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.