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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61862
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Gria2
Name: glutamate ionotropic receptor AMPA type subunit 2
Acc ID: CHEBI:3092
Term: bicuculline
Definition: Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.
Chemical ID: MESH:D001640
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDBicuculline results in decreased expression of GRIA2 mRNA

Bicuculline results in decreased expression of GRIA2 protein

PMID:22262897
multiple interactionsEXP 6480464CTDBicuculline promotes the reaction [MECP2 protein binds to GRIA2 promoter]

Bicuculline results in decreased expression of and results in decreased localization of GRIA2 protein

MECP2 protein affects the reaction [Bicuculline results in decreased expression of GRIA2 protein]

PMID:19674091, PMID:22262897
decreases expressionISOCRRD:621546480464CTDBicuculline results in decreased expression of GRIA2 protein

PMID:22262897
multiple interactionsISOCRRD:621546480464CTDMECP2 protein affects the reaction [Bicuculline results in decreased expression of GRIA2 protein]

PMID:22262897
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