GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2342
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Chrm1
Name: cholinergic receptor, muscarinic 1
Acc ID: CHEBI:3112
Term: biperiden
Definition: A member of the class of piperidines that is N-propylpiperidine in which the methyl hydrogens have been replaced by hydroxy, phenyl, and 5-norbornen-2-yl groups. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease.
Chemical ID: MESH:D001712
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDBiperiden binds to and results in decreased activity of CHRM1 protein

PMID:21336581
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.