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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3122
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Muc1
Name: mucin 1, cell surface associated
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISOCRRD:109276480464CTDFulvestrant results in increased expression of MUC1 mRNA

Fulvestrant results in increased expression of MUC1 protein

PMID:30061528
multiple interactionsISOCRRD:109276480464CTDbisphenol A inhibits the reaction [Fulvestrant results in increased expression of MUC1 mRNA]

Fulvestrant inhibits the reaction [Estradiol results in increased expression of MUC1 mRNA]

Fulvestrant promotes the reaction [4-tert-octylphenol results in increased expression of MUC1 mRNA]

PMID:30061528
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.