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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases phosphorylationEXP 6480464CTDlead acetate results in increased phosphorylation of EGFR protein

PMID:19133285
multiple interactionsEXP 6480464CTD4-((3-bromophenyl)amino)-6, 7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased phosphorylation of EGFR protein], EGFR mutant form inhibits the reaction [lead acetate results in increased activity of PRKCA protein], EGFR mutant form inhibits the reaction [lead acetate results in increased phosphorylation of SRC protein], RTKI cpd inhibits the reaction [lead acetate results in increased phosphorylation of EGFR protein]

PMID:19133285
decreases expressionISORGD:25436480464CTDlead acetate results in decreased expression of EGFR protein

PMID:17298174
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.