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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3389
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Prkaca
Name: protein kinase cAMP-activated catalytic subunit alpha
Acc ID: CHEBI:3216
Term: buprenorphine
Definition: A morphinane alkaloid that is 7,8-dihydromorphine 6-O-methyl ether in which positions 6 and 14 are joined by a -CH2CH2- bridge, one of the hydrogens of the N-methyl group is substituted by cyclopropyl, and a hydrogen at position 7 is substituted by a 2-hydroxy-3,3-dimethylbutan-2-yl group.
Chemical ID: MESH:D002047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDBuprenorphine results in decreased activity of PRKACA protein

PMID:24321744
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