GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2456
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:32234
Term: titanium dioxide
Definition: A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.
Chemical ID: MESH:C009495
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:7372226480464CTDtitanium dioxide results in decreased expression of CYP17A1 mRNA

titanium dioxide results in decreased expression of CYP17A1 protein

PMID:24241477
increases expressionISOCRRD:7372226480464CTDtitanium dioxide results in increased expression of CYP17A1 mRNA

PMID:23131501
multiple interactionsISOCRRD:7372226480464CTD[[titanium dioxide results in decreased expression of CYP17A1 mRNA] co-treated with [titanium dioxide results in decreased expression of HSD17B10 mRNA]] results in increased chemical synthesis of Testosterone

PMID:24241477
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.