GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3952
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Vcam1
Name: vascular cell adhesion molecule 1
Acc ID: CHEBI:32234
Term: titanium dioxide
Definition: A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.
Chemical ID: MESH:C009495
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISOCRRD:114816480464CTDtitanium dioxide results in increased expression of VCAM1 mRNA

PMID:23557971
increases expressionISOCRRD:7309886480464CTDtitanium dioxide results in increased expression of VCAM1 mRNA

titanium dioxide results in increased expression of VCAM1 protein

PMID:22352400, PMID:25526690, PMID:29244817
multiple interactionsISOCRRD:7309886480464CTDCurcumin inhibits the reaction [titanium dioxide results in increased expression of VCAM1 protein]

PMID:29244817
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.