GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620763
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ccn1
Name: cellular communication network factor 1
Acc ID: CHEBI:32293
Term: verteporfin
Definition: An equimolar mixture of the 9-methyl ester and 13-methyl ester of trans-(+-)-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid. It is used as a photosensitizer in photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with neovascular (wet) age-related macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when activated by red (693 nm) laser light in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.
Chemical ID: MESH:C098350
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:7317206480464CTDVerteporfin results in decreased expression of CCN1 mRNA

PMID:29725256
multiple interactionsISOCRRD:7317206480464CTDVerteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA]

PMID:29725256
multiple interactionsISOCRRD:7317216480464CTDVerteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCN1 mRNA]

PMID:29893953
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.