GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2466
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp2b1
Name: cytochrome P450, family 2, subfamily b, polypeptide 1
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDpirinixic acid promotes the reaction [Phenobarbital results in increased activity of CYP2B1 protein]

pirinixic acid promotes the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA]

PMID:18023279, PMID:19631232
decreases expressionISOCRRD:15583116480464CTDpirinixic acid results in decreased expression of CYP2B10 mRNA

PMID:19850644, PMID:20059764, PMID:23811191
increases expressionISOCRRD:15583116480464CTDpirinixic acid results in increased expression of CYP2B10 mRNA

pirinixic acid results in increased expression of CYP2B10 protein

PMID:11798191, PMID:12727805, PMID:15618236, PMID:18445702, PMID:20813756, PMID:28541575
multiple interactionsISOCRRD:15583116480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CYP2B10 mRNA

pirinixic acid inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to CYP2B10 promoter]]

pirinixic acid inhibits the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA]

PPARA protein promotes the reaction [pirinixic acid results in decreased expression of CYP2B10 mRNA]

PMID:17962186, PMID:19710929, PMID:19850644, PMID:20059764
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.