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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2490
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Dbi
Name: diazepam binding inhibitor, acyl-CoA binding protein
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDpirinixic acid affects the expression of DBI mRNA

PMID:19483382
increases expressionEXP 6480464CTDpirinixic acid results in increased expression of DBI mRNA

PMID:19162173
multiple interactionsEXP 6480464CTDpirinixic acid promotes the reaction [[PPARA protein binds to MDM2 protein] which binds to DBI promoter]

PMID:19103650
increases expressionISORGD:104636480464CTDpirinixic acid results in increased expression of DBI mRNA

PMID:17118139, PMID:17426115, PMID:18301758, PMID:20059764, PMID:20813756
multiple interactionsISORGD:104636480464CTDPPARA protein promotes the reaction [pirinixic acid results in increased expression of DBI mRNA]

PMID:20059764
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.