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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3074
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Me1
Name: malic enzyme 1
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDpirinixic acid affects the expression of ME1 mRNA

PMID:19483382
increases expressionEXP 6480464CTDpirinixic acid results in increased expression of ME1 mRNA

PMID:16489205, PMID:19162173, PMID:22484513
increases expressionISORGD:108906480464CTDpirinixic acid results in increased expression of ME1 mRNA, pirinixic acid results in increased expression of ME1 protein

PMID:15226431, PMID:15777286, PMID:16357043, PMID:16489205, PMID:17426115, PMID:20059764, PMID:20813756, PMID:23811191
multiple interactionsISORGD:108906480464CTD[pirinixic acid co-treated with PPARA] results in increased expression of ME1 mRNA, PPARA protein affects the reaction [pirinixic acid results in increased expression of ME1 mRNA], PPARA protein promotes the reaction [pirinixic acid results in increased expression of ME1 mRNA]

PMID:15777286, PMID:16489205, PMID:20059764, PMID:20813756
multiple interactionsISORGD:7361336480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ME1 mRNA

PMID:19710929
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.