RGD Gene Chemical Interaction Report - Chinchilla Research Resource Database

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID:	620585
Species:	Rattus norvegicus
CRRD Object:	Gene
Symbol:	Elovl6
Name:	ELOVL fatty acid elongase 6

Acc ID:	CHEBI:32509
Term:	pirinixic acid
Definition:	An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID:	MESH:C006253

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases activity	EXP		6480464	CTD	pirinixic acid results in increased activity of ELOVL6 protein	PMID:15654130
increases expression	EXP		6480464	CTD	pirinixic acid results in increased expression of ELOVL6 mRNA	PMID:15654130, PMID:27665778
decreases expression	ISO	RGD:1332205	6480464	CTD	pirinixic acid results in decreased expression of ELOVL6 mRNA	PMID:18445702
increases expression	ISO	RGD:1332205	6480464	CTD	pirinixic acid results in increased expression of ELOVL6 mRNA	PMID:16790840, PMID:18467677
multiple interactions	ISO	RGD:1332205	6480464	CTD	PPARA protein affects the reaction [pirinixic acid results in increased expression of ELOVL6 mRNA], PPARA protein promotes the reaction [pirinixic acid results in increased expression of ELOVL6 mRNA]	PMID:16790840, PMID:18467677
multiple interactions	ISO	RGD:1345221	6480464	CTD	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ELOVL6 mRNA	PMID:19710929

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

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