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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 68328
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Slc2a5
Name: solute carrier family 2 member 5
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDpirinixic acid results in decreased expression of SLC2A5 mRNA

PMID:19162173
decreases expressionISORGD:684576480464CTDpirinixic acid results in decreased expression of SLC2A5 mRNA

PMID:20813756, PMID:23811191
multiple interactionsISORGD:684576480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC2A5 mRNA, [pirinixic acid co-treated with PPARA] results in decreased expression of SLC2A5 mRNA

PMID:19710929, PMID:20813756
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.