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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1309970
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Gsta4
Name: glutathione S-transferase alpha 4
Acc ID: CHEBI:32585
Term: 4-hydroxynon-2-enal
Definition: An enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position.
Chemical ID: MESH:C027576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects metabolic processingEXP 6480464CTDGSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal, GSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal analog

PMID:11256969, PMID:11488593, PMID:12600725, PMID:2619714, PMID:7878679
increases expressionEXP 6480464CTD4-hydroxy-2-nonenal results in increased expression of GSTA4 mRNA, 4-hydroxy-2-nonenal results in increased expression of GSTA4 protein

PMID:9799558
affects metabolic processingISORGD:13206016480464CTDGSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal

PMID:10514034, PMID:11162605, PMID:11302754, PMID:11488593, PMID:16005854, PMID:8142470, PMID:8203886, PMID:9461507
multiple interactionsISORGD:13206016480464CTDGSTA4 protein binds to and affects the metabolism of 4-hydroxy-2-nonenal

PMID:15829614
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.