GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1303075
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Hsp90ab1
Name: heat shock protein 90 alpha family class B member 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDbisphenol A results in increased expression of HSP90AB1 mRNA

bisphenol A results in increased expression of HSP90AB1 protein

PMID:15229138, PMID:25181051
multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of HSP90AB1 promoter

PMID:23359474
increases expressionISOCRRD:13468936480464CTDbisphenol A results in increased expression of HSP90AB1 mRNA

PMID:15223131
increases expressionISOCRRD:15525916480464CTDbisphenol A results in increased expression of HSP90AB1 mRNA

PMID:26063408
multiple interactionsISOCRRD:13468936480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HSP90AB1 mRNA

ESR1 protein affects the reaction [bisphenol A results in increased expression of HSP90AB1 mRNA]

PMID:15223131, PMID:28628672
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.