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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1306213
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Pak6
Name: p21 (RAC1) activated kinase 6
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PAK6 mRNA

PMID:25181051
multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Testosterone] results in decreased expression of PAK6 mRNA

PMID:26496021
increases methylationISORGD:13147046480464CTDbisphenol A results in increased methylation of PAK6 promoter

PMID:27312807
multiple interactionsISORGD:13147036480464CTD[bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PAK6 protein modified form]

PMID:28751236
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.