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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1307991
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Sh2d4a
Name: SH2 domain containing 4A
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sh2d4aaffects expressionEXP 6480464CTDbisphenol A affects the expression of SH2D4A mRNA

PMID:25181051
Sh2d4adecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of SH2D4A mRNA

PMID:30816183
Sh2d4aincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of SH2D4A gene

PMID:28505145
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.