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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1593189
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Gsta5
Name: glutathione S-transferase alpha 5
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDbisphenol A affects the expression of GSTA5 mRNA

PMID:25181051, PMID:30903817
increases methylationEXP 6480464CTDbisphenol A results in increased methylation of GSTA5 gene

PMID:28505145
multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in increased expression of GSTA5 mRNA

PMID:26496021
decreases expressionISORGD:13446236480464CTDbisphenol A results in decreased expression of GSTA5 mRNA

PMID:24214726
multiple interactionsISORGD:16201186480464CTD[potassium bromate co-treated with bisphenol A] affects the expression of GSTA5 mRNA, [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of GSTA5 mRNA]

PMID:27082013
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.