Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3910
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tshb
Name: thyroid stimulating hormone subunit beta
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of TSHB mRNA

PMID:25181051, PMID:28167136, PMID:30099086
increases secretionEXP 6480464CTDbisphenol A results in increased secretion of TSHB protein

PMID:29305326
multiple interactionsEXP 6480464CTD[Estradiol co-treated with bisphenol A] results in increased expression of TSHB mRNA, bisphenol A inhibits the reaction [TRH protein results in increased secretion of TSHB protein]

PMID:29305326, PMID:30099086
multiple interactionsISORGD:7326056480464CTDbisphenol A inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]

PMID:19766106
multiple interactionsISORGD:7326066480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased expression of TSHB mRNA

PMID:22828881
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.