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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620575
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDbisphenol A results in increased expression of APAF1 mRNA, bisphenol A results in increased expression of APAF1 protein

PMID:23328667, PMID:25181051, PMID:29097150
increases methylationEXP 6480464CTDbisphenol A results in increased methylation of APAF1 gene

PMID:28505145
decreases expressionISORGD:7332936480464CTDbisphenol A results in decreased expression of APAF1 mRNA, bisphenol A results in decreased expression of APAF1 protein

PMID:21277958, PMID:27685785
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.