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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620904
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Sh3kbp1
Name: SH3 domain-containing kinase-binding protein 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDbisphenol A affects the expression of SH3KBP1 mRNA

PMID:25181051
increases methylationEXP 6480464CTDbisphenol A results in increased methylation of SH3KBP1 gene

PMID:28505145
increases methylationISORGD:7328916480464CTDbisphenol A results in increased methylation of SH3KBP1 promoter

PMID:27312807
multiple interactionsISORGD:7328906480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SH3KBP1 mRNA

PMID:28628672
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.